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Hepatic biotransformation of MLN8054 was studied in vitro making use of human liver S9 fractions (Knowledge on file, Millennium). Glucuronidation of the carboxylate moiety of MLN8054 to an acyl glucuronide was the predominant mechanism of biotransformation, Hydroxylation from the azepine moiety of MLN8054 was the major phase one biotransformation p
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